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ISSCR Newsletter Editor's Note Your feedback and submissions to this newsletter are encouraged. Send information, updates, calendar listings, citations and other material for consideration to the editor at sxk79@po.cwru.edu or to ISSCR Headquarters at psullivan@isscr.org. Lastly, I encourage you to forward this newsletter to individuals who might be interested in joining our new stem cell research society.
Dear Members: The ISSCR continues to grow in its membership and one of its missions is to provide interconnectivity to researchers, the lay public, government and reporters. Perhaps the best mechanism for our Society to establish this communication is through our website. We are in the process of securing funding to allow us to alter our website so that it is a better interactive source of information. Below I have listed our goals with respect to the website. I am looking for feedback and also interesting ideas that we can list on the website. We plan to utilize state of the art graphics with language that can be understood by the lay audience as well as experienced investigators. The improvement in the website will be predominantly based on two aspects: 1) improvement in design; and 2) the hiring of dedicated individuals who are focused on the website. In particular, one individual will work on the daily upkeep and the creation of new links. The other person will focus on scientific aspects regarding stem cell biology, community and interactions among investigators in the field, members of the ISSCR, as well as interactions with other foundations. The following items will be included on the website: 1) Definitions. Even in its perfunctory form, we have found that many reporters and government officials are utilizing the website for definitions of terminology. We plan to update these definitions. Such definitions will remain simple and straightforward, and in the future could be illustrated. For instance, the process of nuclear cloning will be described for senior investigators and for the lay public. 2) Ethical Discussions. The Board is lucky to have Laurie Zoloth as a member. She has been extremely influential in the bioethics of stem cells and has authored several publications and books on this matter. We plan to develop ethical statements that will be posted on our website. This can then be utilized by government officials, as well as reporters, for a better understanding and promotion of discussion among the various groups developing opinions on stem cell derivation and use. We also plan to develop position statements for the ISSCR. For instance, Rudy Janesch has developed a statement on cloning that is currently being reviewed by our Policy Committee. This will be posted on our website. 3) Literature search. It is very important that the stem cell field maintain up-to-date resources. For instance, I was recently asked by the Australian government for a complete compilation of stem cell literature regarding the use of human embryonic stem cells. It was possible to obtain the National Academy of Sciences reports and a link from our website, but it would also be important to proactively generate literature searches that could be used for a variety of purposes. 4) Bringing membership together. Our website will link stem cell researchers. Since our membership encompasses much of the community and in particular, our Board and committee members form many of the leaders, we think we are in a unique position to bring stem cell researchers together through our website. Our website will list contact information for members and searchable areas of expertise (using key words). Over the next couple of years, we will develop user groups among stem cell researchers, lay people and government officials. This will allow links so that information about stem cell biology can be available to the community and potential collaborations can be fostered. 5) Job searching. It is clear that a number of academic institutes and industry are now generating stem cell biology jobs, including professorships and junior faculty. It is critical to hire high quality investigators and this can be advertised through our website. 6) Grant opportunities for stem cell researchers. It is clear that there are many mechanisms to fund stem cell researchers. Many institutions, associations, and foundations want a better view of the investigators and topics relevant to their interests. This aspect of the website will be invaluable for furthering the field as we attempt to bring stem cells to the bedside. This may be an excellent resource for initiating collaborations. 7) Creating new alliances. Several academic websites have links to stem cell biology. Interconnectivity is very important and the website. The connector of these sites will be facilitated with a dedicated person working on the science of the field. 8) Meetings. There are numerous stem cell meetings and a focused website delineating these times and places will be extremely useful for the community. 9) Storage of Newsletters. We plan to create a library of our Newsletters, so that new members can have up-to-date information. 10) Listing of available Human ES and EG lines. As many of you know, there are currently only a few lines available. The website can list these with information such as karyotype analysis, etc. As you can see, this is an all encompassing plan. Our hope is that the hiring of a full time science editor will facilitate many of these goals and will establish more connections within the stem cell field. Sincerely, Leonard
I. Zon, M.D. Human stem cell bank: Availability of NIH-approved human ES cell lines: Although a long list of human embryonic stem cell lines has been approved by the NIH for use in federally funded US labs, actual availability seems to have been scarce up to now. The NIH awarded several infrastructure grants to facilitate growing and distribution of the approved cell lines. Hopefully the supply bottleneck will soon be passed. If
you have cell lines included in the NIH list in your laboratory
and need additional support for distribution to the research community,
please contact:
Australia:
Canada: European
Union: Austria,
Italy, Ireland and Spain: Belgium: Germany: France: Netherlands: Sweden: United
Kingdom: India: Israel: Japan: Korea: Singapore: United
States: Announcement by Una Chen, PhD, Head of the Stem Cell Therapy Program at the University of Giessen (Germany): Dear Colleagues, We
are planning a publication on the origins of stem cell research
Much
attention has been drawn recently to stem cells. It has become You
are more than welcome to spread the word to people who may not Una
Chen, Ph.D.-U.C.Berkeley UNITED KINGDOM: Alzheimer's
Research Trust: Research
into Aging: GERMANY: Humboldt
Research Fellowship Program: UNITED STATES: NIGMS
The
receipt date for this RFA is March 13, 2003. Details of these initiatives
can be found at http://www.nigms.nih.gov/funding/stemcells.html.
In addition, this site contains links to the report of the NIGMS
Workshop on the Basic Biology of Mammalian Stem Cells and to other
resources for human embryonic stem cell research. State
of New Jersey Commission on Spinal Cord Research McKnight
Endowment Fund for Neuroscience: 2002 October
15-19 November
18-20 December 6-10 2003 June
8-11 January
30-February 3 February
13-18 March
13-14 June
4-8 June
13-18 July
5-9 July
30-August 2 Keystone
Symposia of potential interest: January
21-26 February
11-16 March
29-April 3 Send
meetings to be listed in the calendar to ISSCR headquarters:
January 15-16 Reports and Discussion Papers by the Nuffield Council on Bioethics, London, U.K.: http://www.nuffieldbioethics.org Reports
and Discussion papers among others, on: Copies in CD-ROM form of reports and discussion papers can also be requested at bioethics@nuffieldfoundation.org, or downloaded from their website. Reviews July Issue of Journal of Pathology, vol 197, with reviews on prostatic, neural, lung epithelial, pancreatic, hepatic, gastrointestinal, epidermal, cardiac, muscle, hematopoietic, and embryonic stem cells. Burdon T, Smith A, Savatier P (2002)."Signalling, cell cycle and pluripotency in embryonic stem cells."Trends Cell Biol 12:432. Bradley JA, Bolton EM, Pedersen RA (2002). "Stem cell medicine encounters the immune system." Nat Rev Immunol. 2:859. Daley G (2002)."Prospects for stem cell therapeutics: myths and medicines." Curr Opin Genet Dev 12:607. Eiges R, Benvenisty N (2002)."A molecular view on pluripotent stem cells." FEBS Lett 529:135. Frisen J (2002)."Stem cell plasticity?" Neuron 35:415. Noel D, Djouad F, Jorgense C (2002). "Regenerative medicine through mesenchymal stem cells for bone and cartilage repair." Curr Opin Investig Drugs 3:1000. Presnell S, Petersen B, Heidaran M (2002)."Stem cells in adult tissues." Semin Cell Dev Biol 13:369. Tisdale JF, Dunbar CE (2002)."Plasticity and hematopoiesis: Circe's transforming potion?" Curr Opin Hematol 9:268. Weissman IL (2002). "The road ended up at stem cells." Immunol Rev. 185:159. Wilmut I, Beaujean N, De Sousa PA, Dinnyes A, King TJ, Paterson LA, Wells DN, Young LE (2002)."Somatic cell nuclear transfer." Nature 419:583. Asano T, Hanazono Y, Ueda Y, Muramatsu S, Kume A, Suemori H, Suzuki Y, Kondo Y, Harii K, Hasegawa M, Nakatsuji N, Ozawa K (2002)."Highly efficient gene transfer into primate embryonic stem cells with a simian lentivirus vector." Mol Ther 6:162. Falk A, Holmstrom N, Carlen M, Cassidy R, Lundberg C, Frisen J (2002)."Gene delivery to adult neural stem cells." Exp Cell Res 279:34. Fijnvandraat AC, De Boer PA, Deprez RH, Moorman AF (2002)."Non-radioactive in situ detection of mRNA in ES cell-derived cardiomyocytes and in the developing heart." Microsc Res Tech 58:387. Levsky JM, Shenoy SM, Pezo RC, Singer RH. (2002). "Single-cell gene expression profiling." Science, 297:836. Murphy CL, Polak JM (2002)."Differentiating Embryonic Stem Cells: GAPDH, But Neither HPRT Nor beta-Tubulin Is Suitable as an Internal Standard for Measuring RNA Levels." Tissue Eng 8:551. Nagano M, Watson DJ, Ryu BY, Wolfe JH, Brinster RL (2002)." Lentiviral vector transduction of male germ line stem cells in mice." FEBS Lett 524:111. Pedersen
RA (2002)."Feeding hungry stem cells." Nat Biotechnol
20:882-3. Castro, RF, Jackson KA, Goodell MA, Robertson CS, Liu H, Shine HD (2002)." Failure of bone marrow cells to transdifferentiate into neural cells in vivo." Science 297:1299. Drukker M, Katz G, Urbach A, Schuldiner M, Markel G, Itskovitz-Eldor J, Reubinoff B, Mandelboim O, Benvenisty N (2002)."Characterization of the expression of MHC proteins in human embryonic stem cells." Proc Natl Acad Sci U S A 99:9864. Hackney JA, Charbord P, Brunk BP, Stoeckert CJ, Lemischka IR, Moore KA (2002)."A molecular profile of a hematopoietic stem cell niche." Proc Natl Acad Sci U S A 99:13061. Hanna LA, Foreman RK, Tarasenko IA, Kessler DS, Labosky PA (2002)."Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo." Genes Dev 20:2650. Heyworth C, Pearson S, May G, Enver T (2002)."Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells." EMBO J. 21:3770. Humpherys D, Eggan K, Akutsu H, Friedman A, Hochedlinger K, Yanagimachi R, Lander ES, Golub TR, Jaenisch R (2002)."Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei." Proc Natl Acad Sci U S A 99:12889. Ivanova
NB, Dimos JT, Schaniel C, Hackney JA, Moore KA, Lemischka IR (2002). Jirmanova
L, Afanassieff M, Gobert-Gosse S, Markossian S, Savatier P (2002)."
Differential contributions of ERK and PI3-kinase to the regulation
of cyclin D1 expression and to the control of the G1/S transition
in mouse embryonic stem cells." Kim JH, Auerbach JM, Rodriguez-Gomez JA, Velasco I, Gavin D, Lumelsky N, Lee SH, Nguyen J, Sanchez-Pernaute R, Bankiewicz K, McKay R. (2002) "Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease." Nature, 418:50. Ramalho-Santos M, Yoon S, Matsuzaki Y, Mulligan RC, Melton DA (2002). "Stemness": transcriptional profiling of embryonic and adult stem cells." Science 298:597. Schmidt M, Zickler P, Hoffmann G, Haas S, Wissler M, Muessig A, Tisdale JF, Kuramoto K, Andrews RG, Wu T, Kiem HP, Dunbar CE, von Kalle C (2002)."Polyclonal long-term repopulating stem cell clones in a primate model." Blood. 100:2737. Tsai EJ, Malech HL, Kirby MR, Hsu AP, Seidel NE, Porada CD, Zanjani ED, Bodine DM, Puck JM (2002)."Retroviral transduction of IL2RG into CD34(+) cells from X-linked severe combined immunodeficiency patients permits human T- and B-cell development in sheep chimeras." Blood100:72. Wagers AJ, Sherwood RI, Christensen JL, Weissman IL (2002)."Little evidence for developmental plasticity of adult hematopoietic stem cells." Science 297:2256. Xu C, Police S, Rao N, Carpenter MK (2002). Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells."Circ Res 91:501. © 2002 All rights reserved. International Society for Stem Cell Research |
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